New research indicates that people who stop using new weight-loss injections like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who halt conventional diet and exercise programs.
Research printed in a prominent medical journal demonstrates that while obese people can lose substantial amounts of their body weight while on the medication, the weight returns at an estimated rate of 0.8 kg per month upon discontinuation.
"People buying such treatments need to be cognizant of the risk of quick rebound weight gain when the treatment is stopped," stated lead investigator Dr. Susan Jebb.
Such speed of recovery implies a return to pre-treatment mass in about 18 months.
Analyzing Approaches
The research, which reviewed dozens of trials involving thousands of patients, compared the effects of GLP-1 agonists with older methods.
The team note that individuals who lose weight through diet and exercise generally see a more gradual creep back—approximately 100 grams monthly—post-intervention.
Explaining the Fast Rebound
Doctors propose the way of the jabs explains the heightened rebound.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Sustained high doses of GLP-1 concentrations far above than the body's typical production could lead to the system to generate a reduced amount of its own natural hormone, and could diminish responsiveness to its effects," noted Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this GLP-1 'fix' leads to hunger is no longer kept in check, making excessive eating far more likely."
A Chronic Disease?
The NHS suggest the injections for individuals with obesity-related health risks, accompanied by recommended lifestyle changes.
Many experts say that, considering the high risk of weight regain, the therapy is often ongoing.
This opinion is supported by pharmaceutical companies, who state that the results "underscore the long-term character of excess weight," similar to managing diseases like diabetes.
User Testimonies
People who have stopped the jabs describe a intense resurgence of cravings.
"It felt as if a switch activating and you become extremely hungry," recalled an individual.
The struggle is worsened if patients have not established permanent lifestyle or habit modifications during treatment.
Growing Interest
Figures suggest that a significant number of adults in the UK have used weight-loss jabs in the last 12 months, with desire remaining high.
- Adoption is greater among females than males.
- The 40s and 50s demographic shows the greatest level of interest.
- Many obtain the medications through private healthcare rather than the NHS.
Ultimately, clinicians caution that while these medications are potent agents for weight loss, they are not a permanent fix and lasting health benefits likely depends on combined lifestyle changes.
